High-Yield Methods for Accurate Two-Alternative Visual Psychophysics in Head-Fixed Mice
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چکیده
منابع مشابه
High-Yield Methods for Accurate Two-Alternative Visual Psychophysics in Head-Fixed Mice
Research in neuroscience increasingly relies on the mouse, a mammalian species that affords unparalleled genetic tractability and brain atlases. Here, we introduce high-yield methods for probing mouse visual decisions. Mice are head-fixed, facilitating repeatable visual stimulation, eye tracking, and brain access. They turn a steering wheel to make two alternative choices, forced or unforced. L...
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Psychophysical tasks for non-human primates have been instrumental in studying circuits underlying perceptual decision-making. To obtain greater experimental flexibility, these tasks have subsequently been adapted for use in freely moving rodents. However, advances in functional imaging and genetic targeting of neuronal populations have made it critical to develop similar tasks for head-fixed m...
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Rats and mice receive a constant bilateral stream of tactile information with their large mystacial vibrissae when navigating in their environment. In a two-alternative forced choice paradigm (2-AFC), head-fixed rats and mice learned to discriminate vibrotactile frequencies applied simultaneously to individual whiskers on the left and right sides of the snout. Mice and rats discriminated 90-Hz ...
متن کاملVisual psychophysics
Visual processes in the brain enable us to make sense of the complex, ever-changing array of shapes and colours that arrives at our eyes. Psychophysics is the research strategy that seeks to understand these processes, by testing the relationship between the ‘psychic’ — what an observer sees and reports — and variations in the physical pattern of light and colour. For 19th century pioneers such...
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BACKGROUND The preparation consisting of a head-fixed mouse on a spherical or cylindrical treadmill offers unique advantages in a variety of experimental contexts. Head fixation provides the mechanical stability necessary for optical and electrophysiological recordings and stimulation. Additionally, it can be combined with virtual environments such as T-mazes, enabling these types of recording ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.08.047